Acute kidney injury (AKI) is a primarily described complication after unbalanced systemic perfusion in neonates with congenital\nheart defects, including hypoplastic left heart syndrome (HLHS). The aim of the study was to compare the umbilical NGAL\nconcentrations between neonates born with HLHS and healthy infants, as well as to analyze whether the determination of NGAL\nlevel could predict AKI in neonates with prenatally diagnosed HLHS. Twenty-one neonates with prenatally diagnosed HLHS were\nenrolled as study group and 30 healthy neonates served as controls. Perinatal characteristics and postnatal parameterswere extracted\nfromthe hospital neonatal database. In umbilical cord blood, we determined plasma NGAL concentrations, acid base balance, and\nlactate and creatinine levels. In neonates with HLHS, complications (respiratory insufficiency, circulatory failure, NEC, IVH, and\nAKI) were recorded until the day of cardiosurgery.We observed in neonates with HLHS higher umbilical NGAL levels compared\nto controls. Among 8 neonates with HLHS and diagnosed AKI stage 1, we observed elevated NGAL levels in comparison to those\nnewborns without AKI. Umbilical NGAL could predict, with high sensitivity and specificity, AKI development in study neonates.\nWe suggest that the umbilical blood NGAL concentration may be an early marker to predict AKI in neonates with HLHS.
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